3-methyl toxoflavin
3-methyl toxoflavin
CAS: 32502-62-8
Molecular Formula: C8H9N5O2
3-methyl toxoflavin - Names and Identifiers
| Name | 3-methyl toxoflavin |
| Synonyms | 3-methyl toxoflavin Pyrimido[5,4-e]-1,2,4-triazine-5,7(1H,6H)-dione, 1,3,6-trimethyl- |
| CAS | 32502-62-8 |
3-methyl toxoflavin - Physico-chemical Properties
| Molecular Formula | C8H9N5O2 |
| Molar Mass | 207.19 |
| Density | 1.56±0.1 g/cm3(Predicted) |
| Boling Point | 285.0±23.0 °C(Predicted) |
| Solubility | DMSO : 150 mg/mL (723.97 mM; Need ultrasonic) |
| pKa | -1.80±0.20(Predicted) |
| Storage Condition | -20°C |
| In vitro study | 3-Methyltoxoflavin is a potent Protein disulfide isomerase (PDI) inhibitor, with an IC 50 of 170 nM. 3-Methyltoxoflavin is toxic in a panel of human glioblastoma cell lines. From the screen, 3-Methyltoxoflavin emerges as the most cytotoxic inhibitor of PDI. Bromouridine labeling and sequencing (Bru-seq) of nascent RNA reveals that 3-Methyltoxoflavin induces Nrf2 antioxidant response, ER stress response, and autophagy. Specifically, 3-Methyltoxoflavin upregulates heme oxygenase 1 and SLC7A11 transcription and protein expression and represses PDI target genes such as TXNIP and EGR1. Interestingly, 3-Methyltoxoflavin-induced cell death does not proceed via apoptosis or necrosis, but by a mixture of autophagy and ferroptosis. |
3-methyl toxoflavin - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 4.827 ml | 24.133 ml | 48.265 ml |
| 5 mM | 0.965 ml | 4.827 ml | 9.653 ml |
| 10 mM | 0.483 ml | 2.413 ml | 4.827 ml |
| 5 mM | 0.097 ml | 0.483 ml | 0.965 ml |
Last Update：2024-01-02 23:10:35
3-methyl toxoflavin - Reference Information
| biological activity | 3-Methyltoxoflavin is a potent inhibitor of protein disulfide isomerase (PDI) with an IC50 value of 170 nM. |
| Target | IC50: 170 nM (PDI). |
Last Update：2024-04-10 22:29:15
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